Ceftriaxone sodium injection for lower respiratory tract infection, urinary tract, biliary tract infection caused by sensitive pathogenic bacteria, as well as abdominal infection, pelvic infection, skin and soft tissue infection, bone and joint infection, sepsis, meningitis, etc. Infection prevention. This product can treat simple gonorrhea in a single dose.
[Chinese name] ceftriaxone sodium for injection
[Indications] For lower respiratory tract infections caused by sensitive pathogens, urinary tract, biliary tract infections, as well as abdominal infections, pelvic infections, skin and soft tissue infections, bone and joint infections, sepsis, meningitis, etc. and prevention of infection during surgery. This product can treat simple gonorrhea in a single dose.
Pharmaceutical properties: This product is white or off-white crystalline powder; odorless.
[Pharmacological action] This product is a third-generation cephalosporin antibiotic. It has strong activity against Enterobacteriaceae bacteria. The MIC90 for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, F. fluorescens, Proteus mirabilis, Pluvidenella and Serratia is between 0.12 and 0.25 mg/ Between L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa have poor sensitivity to this product.
[Drug interaction] 1. Add erythromycin, tetracycline, amphotericin B, vasoactive drugs (m-hydroxylamine, norepinephrine, etc.), phenytoin, chlorpromazine, isopropanol to cephalosporin intravenous infusion. , vitamin B family, vitamin C, etc. will appear turbid. Because this product has a lot of contraindications, it should be administered alone. 2. When using this product during drinking or taking alcoholic drugs, there may be a disulfiram-like reaction in individual patients. Therefore, during the application of this product and within a few days, alcohol and alcohol-containing drugs should be avoided.
[Adverse reactions] Adverse reactions are related to the dose and course of treatment. Local reactions include phlebitis (1.86%), in addition to rash, itching, fever, bronchospasm and serum sickness (2.77%), headache or dizziness (0.27%), diarrhea, nausea, vomiting, abdominal pain, colitis Digestive tract reactions such as jaundice, flatulence, taste disturbance and indigestion (3.45%). Laboratory abnormalities were about 19%, with abnormal hematology accounting for 14%, including eosinophilia, thrombocytosis or reduction, and leukopenia. Patients with abnormal liver and kidney function were 5% and 1.4%.
[Usage and Dosage] General infection, 1g daily, 1 intramuscular injection or intravenous injection. Severe infection, 2g daily, given in 2 divided doses. Meningitis can be given in two doses of 100 mg/kg per day (but not more than 4 g in total). Gonorrhea, a single dose of 250mg is sufficient. The amount of children is generally given in 1/2 of the adult amount. Intramuscular injection: One dose is dissolved in an appropriate amount of 0.5% lidocaine hydrochloride injection for deep intramuscular injection. Intravenous injection: Dissolve 1 g of the drug in 10 ml of sterile water for injection and slowly inject for 2-4 minutes. Intravenous infusion: 1 g in an adult or 2 g in 1 day, dissolved in isotonic sodium chloride injection or 50-100 ml of 5%-10% glucose solution, and instilled within 0.5-1 hour.
[Pharmaceutical Ingredients] The main component of this product is ceftriaxone sodium, and its chemical name is (6R,7R)-7[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8- Oxo-3-[[(1,2,5,6-tetrahydro-2-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio] Methyl]-5-thio-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt triplohydrate.
Folding edit this paragraph taboos and precautions
[Pregnant women medication] Although the use of cephalosporins in pregnant women and lactating women has not yet reported problems, its application still has to weigh the pros and cons.
[Children's medication] The safety of medication for newborns (born less than 2 kg) has not been determined. Newborns with jaundice or neonates with severe jaundice should be used with caution or avoid using this product.
Precautions
1. Cross-allergic reactions: People who are allergic to a cephalosporin or cephamycin may also be allergic to other cephalosporins or cephalosporins.
2. When applying this product to patients with penicillin allergy, it should be decided after weighing the pros and cons according to the patient's condition. Those who have penicillin anaphylactic shock or immediate response should not use cephalosporins.
3. Those with a history of gastrointestinal disease, especially ulcerative colitis, Crohn's disease or antibiotic-associated colitis (cephalosporin rarely produces pseudomembranous colitis) should be used with caution.
4. Due to the low toxicity of cephalosporins, patients with chronic liver disease do not need to adjust the dose when applying this product. Patients with severe liver and kidney damage or cirrhosis should adjust the dose.
5. In patients with renal insufficiency, creatinine clearance is greater than 5m1/min. When the dose of this product is less than 2g per day, no dose adjustment is needed. The amount of this product is not much removed by hemodialysis, and there is no need to supplement the dose after dialysis.
6. Interference with diagnosis: Patients who use this product can obtain false positive reaction when measuring urine sugar by copper sulfate method.
7. The storage temperature of this product is below 25 °C.
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