Ampicillin sodium injection is a medicine used to treat respiratory infections caused by sensitive bacteria.
Type of medicine
Anti-infectives
Fold to edit this paragraph function and indications
It is suitable for respiratory infections, gastrointestinal infections, urinary tract infections, soft tissue infections, endocarditis, meningitis, sepsis, etc. caused by sensitive bacteria.
Collapse edit this paragraph of drug properties
This product is white or almost white powder or crystal.
The pharmacological effects of this paragraph
Ampicillin sodium is a broad-spectrum semi-synthetic penicillin. This product has a strong antibacterial effect on hemolytic streptococcus, streptococcus pneumoniae and staphylococcus that does not produce penicillinase, which is similar to or slightly inferior to penicillin. Ampicillin also has a good antibacterial effect on Streptococcus viridans, and is better than penicillin on Enterococcus and Listeria spp. This product has antibacterial activity against Corynebacterium diphtheria, Bacillus anthracis, Actinomycetes, Haemophilus influenzae, Bordetella pertussis, Neisseria and anaerobic bacteria except Bacteroides fragilis. Some Proteus mirabilis, Escherichia coli, Salmonella and Shigella bacteria are sensitive to this product. Ampicillin exerts a bactericidal effect by inhibiting bacterial cell wall synthesis.
Collapse edit this paragraph interaction
1. Combined use with probenecid will prolong the half-life of this product. 2. Ampicillin and kanamycin have a synergistic antibacterial effect on Escherichia coli Proteus. 3. This product should be instilled separately, and not in the same bottle with the following drugs: aminoglycoside drugs, clindamycin phosphate, lincomycin hydrochloride, polymyxin B, succinic chloramphenicol, erythromycin, Epinephrine, meta-hydroxyamine, dopamine, atropine, calcium gluconate, vitamin B group, vitamin C, nutritional injections containing amino acids, and hydrocortisone succinate, etc. 4. Allopurinol can increase the incidence of ampicillin rash reactions, especially in hyperuricemia. 5. Ampicillin can stimulate the metabolism of estrogen or reduce its hepato-intestinal circulation, thus reducing the effect of oral contraceptives.
Collapse edit this paragraph adverse reactions
The adverse reactions of this product are similar to penicillin, and allergic reactions are more common. Skin rash is the most common reaction, which usually occurs 5 days after medication, showing urticaria or maculopapular rash; interstitial nephritis can also occur; anaphylactic shock is occasional. Once it occurs, it must be rescued locally to keep the airway open. Oxygen and adrenaline, glucocorticoid and other treatment measures. Granulocyte and thrombocytopenia are occasionally seen in patients receiving ampicillin. Antibiotic-related enteritis is rare, and a small number of patients have elevated serum transaminases. Intravenous administration of large doses of ampicillin may cause neurotoxic symptoms such as convulsions. After the application of ampicillin, infants may experience increased intracranial pressure, which is manifested as bregma.
Collapse edit this paragraph product specifications
0.5g (according to C16H19N3O4S)
Medication for pregnant women
There is no strict controlled trial of this product in pregnant women, so pregnant women should only use this product when really necessary. A small amount of this product is secreted from breast milk, and breastfeeding women should stop breastfeeding when taking the drug.
Collapse edit this paragraph usage and dosage
Adults: intramuscular injection of 2 to 4 g a day, divided into 4 doses; intravenous drip or injection dose of 4 to 8 g a day, divided into 2 to 4 doses. The daily dose for severely infected patients can be increased to 12g, and the maximum daily dose is 14g. Children: intramuscular injection is administered in 4 times according to the weight of 50-100mg/kg per day; intravenous drip or injection is administered in 2 to 4 times according to the weight of 100-200mg/kg per day. The highest daily dose is 300 mg/kg based on body weight. Full-term newborns: 12.5~5mg/kg according to body weight once, once every 12 hours on the first and second day of birth, once every 8 hours on the third day to two weeks, and once every 6 hours thereafter. Premature infants: In the first week, 1 to 4 weeks and more than 4 weeks of birth, 12.5 to 50 mg/kg of body weight each time, once every 12 hours, 8 hours and 6 hours, respectively, intravenous drip administration. Renal insufficiency: When the endogenous creatinine clearance rate is 10-50ml/min or less than 10ml/min, the dosing interval should be extended to 6-12 hours and 12-24 hours, respectively. The higher the concentration of ampicillin sodium solution, the worse the stability. 1% Ampicillin Sodium solution can maintain its biological potency for 7 days at 5°C, but it is 24 hours for a 5% solution. Ampicillin sodium intravenous drip solution with a concentration of 30mg/ml can maintain at least 90% of its titer at room temperature for 2-8 hours, and it can maintain 90% of its titer for 72 hours when placed in a refrigerator. Stability can be reduced due to the presence of glucose, fructose and lactic acid, and it also decreases with increasing temperature. For intramuscular injection, it can dissolve 125mg, 500mg and 1g ampicillin sodium in 0.9~1.2ml, 1.2~1.8ml and 2.4~7.4ml sterile water for injection respectively. The concentration of ampicillin sodium intravenous drip should not exceed 30mg/ml.
Storage method of this section
Seal tightly and store in a dry place.
Notes for editing this paragraph
1. Before applying this product, a detailed history of drug allergy and penicillin skin test should be conducted.
2. Patients with infectious mononucleosis, cytomegalovirus infection, lymphocytic leukemia, and lymphoma are prone to skin rashes when using this product and should be avoided.
3. This product must be freshly prepared.
Fold edit this paragraph of instructions
common name
Ampicillin Sodium for Injection
Indications
Ampicillin Sodium for Injection
It is suitable for respiratory infections, gastrointestinal infections, urinary tract infections, soft tissue infections, endocarditis, meningitis, sepsis, etc. caused by sensitive bacteria.
Traits
This product is white or almost white powder or crystal.
Dosage
Adults: intramuscular injection of 2 to 4 g a day, divided into 4 doses; intravenous drip or injection dose of 4 to 8 g a day, divided into 2 to 4 doses. The daily dose for severely infected patients can be increased to 12g, and the maximum daily dose is 14g. Children: intramuscular injection is administered in 4 times according to the weight of 50-100mg/kg per day; intravenous drip or injection is administered in 2 to 4 times according to the weight of 100-200mg/kg per day. The maximum daily dose is 300 mg/kg based on body weight. Full-term newborn: 12.5~25mg/kg according to body weight once, once every 12 hours on the 1st and 2nd day of birth, once every 8 hours on the third day~2 weeks, and once every 6 hours thereafter. Premature infants: 12.5-50 mg/kg of body weight in the first week, 1 to 4 weeks and more than 4 weeks of birth, once every 12 hours, 8 hours and 6 hours, intravenously. Renal insufficiency: When the endogenous creatinine clearance rate is 10-50ml/min or less than 10ml/min, the dosing interval should be extended to 6-12 hours and 12-24 hours, respectively. The higher the concentration of ampicillin sodium solution, the worse the stability. 1% Ampicillin Sodium solution can maintain its biological potency for 7 days at 5°C, but it is 24 hours for a 5% solution. Ampicillin sodium intravenous drip with a concentration of 30mg/ml can maintain at least 90% of its titer at room temperature for 2-8 hours, and it can maintain 90% of its titer for 72 hours when placed in a refrigerator. Stability can be reduced due to the presence of glucose, fructose and lactic acid, and it also decreases with increasing temperature. For intramuscular injection, it can dissolve 125mg, 500mg and 1g ampicillin sodium in 0.9~1.2ml, 1.2~1.8ml and 2.4~7.4ml sterile water for injection respectively. The concentration of ampicillin sodium intravenous drip should not exceed 30mg/ml.
Adverse reactions
The adverse reactions of this product are similar to penicillin, and allergic reactions are more common. Skin rash is the most common reaction, which usually occurs 5 days after medication, showing urticaria or maculopapular rash; interstitial nephritis can also occur; anaphylactic shock is occasional. Once it occurs, it must be rescued locally to keep the airway open. Oxygen and adrenaline, glucocorticoid and other treatment measures. Granulocyte and thrombocytopenia are occasionally seen in patients receiving ampicillin. Antibiotic-related enteritis is rare, and a small number of patients have elevated serum transaminases. Intravenous administration of large doses of ampicillin can cause neurological toxic symptoms such as convulsions. After the application of ampicillin, infants can experience increased intracranial pressure, which is manifested as pro-halogen bulge.
Contraindications
Patients with a history of penicillin allergy or a positive penicillin skin test should not be used.
Precautions
1. Before applying this product, a detailed history of drug allergy and penicillin skin test should be conducted. 2. Patients with infectious mononucleosis, cytomegalovirus infection, lymphocytic leukemia, and lymphoma are prone to skin rashes when using this product and should be avoided. 3. This product must be freshly prepared. Medication for pregnant women and lactating women: There are no strict controlled trials of this product in pregnant women, so pregnant women should only use this product when it is really necessary. A small amount of this product is secreted from breast milk, and breastfeeding women should stop breastfeeding when taking the drug.
medicine interactions
1. Combined use with probenecid will prolong the half-life of this product. 2. Ampicillin and kanamycin have a synergistic antibacterial effect on Escherichia coli and Proteus. 3. This product should be instilled separately, not in the same bottle with the following drugs: aminoglycoside drugs, clindamycin phosphate, lincomycin hydrochloride, polymyxin B, succinic chloramphenicol, erythromycin, Adrenaline, meta-hydroxyamine, dopamine, atropine, calcium gluconate, vitamin B group, vitamin C, nutritional injections containing amino acids, and hydrocortisone succinate, etc. 4. Allopurinol can increase the incidence of ampicillin rash reactions, especially in hyperuricemia. 5. Ampicillin can stimulate the metabolism of estrogen or reduce its hepato-intestinal circulation, thus reducing the effect of oral contraceptives.
Specification
Ampicillin Sodium for Injection (1) 0.5g; (2) 1g
Audited Supplier 
){kind=link}