INDICATION:
Nystatin Vaginal Tablets, USP are effective for the local treatment of vulvovaginal candidiasis (moniliasis). The diagnosis should be confirmed, prior to therapy, by KOH smears and/or cultures. Other pathogens commonly associated with vulvovaginitis (Trichomonas and Haemophilus vaginalis ) do not respond to nystatin and should be ruled out by appropriate laboratory methods
Nystatin is a polyene antifungal drug to which many molds and yeast infections are sensitive, including Candida.
Cutaneous, vaginal, mucosal and esophageal Candida infections usually respond well to treatment with nystatin.
Like amphotericin B and natamycin, nystatin binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage and death of the fungus. Ergosterol is fairly unique to fungi, so the drug does not have such catastrophic effects on animals
Nystatin is often used as prophylaxis in patients who are at risk for fungal infections
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