Paracetamol, the product name is Baifuning, Bilitong, Tylenol, acetaminophen and so on. The international non-proprietary drug name is
Paracetamol. It is the most commonly used non-anti-inflammatory, antipyretic and analgesic. Its antipyretic effect is similar to that of aspirin.
Its analgesic effect is weak. It has no anti-inflammatory and anti-rheumatic effects. It is the best variety of acetanilide drugs. It is especially suitable
for patients who cannot use carboxylic acid drugs. Used for colds, toothaches and other diseases. Acetaminophen is also an intermediate in organic
synthesis, a stabilizer of hydrogen peroxide, and a photographic chemical.
Chinese alias: paracetamol, acetaminophen, paracetamol, antipyretic net, acetaminophen, paracetamol, somitong, acetaminophen, diacetolol.
English name: 4-Acetamido phenol, paracetamol or acetaminophen.
English alias: Acetamino phen, 4-Hydroxyacetanilide, APAP, p-Hydroxyacetanilide, Paracetamol (Acetaminophen).
Quality standard: BP\USP.
Content: 99%-101%.
CAS number: 103-90-2.
Molecular formula: C8H9NO2.
Molecular weight: 151.16.
Physical and chemical properties: White crystalline powder, odorless, soluble in hot water, ether, chloroform, etc.
Product use: Antipyretic and analgesic.
Pharmacology
Pharmacodynamics This product is an acetanilide antipyretic and analgesic. By inhibiting cyclooxygenase, it selectively inhibits the synthesis of prostaglandins in the hypothalamic body temperature regulation center, leading to peripheral blood vessel dilation and sweating to achieve antipyretic effect. Its antipyretic effect is similar to aspirin; by inhibiting the synthesis of prostaglandins, etc. It is a peripheral analgesic, and its effect is weaker than that of aspirin. It is only effective for mild to moderate pain. This product has no obvious anti-inflammatory effect.
Pharmacokinetics After oral administration, it is quickly and completely absorbed from the gastrointestinal tract (taking the drug after a high-carbohydrate diet may reduce absorption), and is evenly distributed in body fluids after absorption, and about 25% is bound to plasma proteins. In small amounts (blood drug concentration <60μg/ml), the binding to protein is not obvious, and in large amounts or in toxic amounts, the binding rate is higher, up to 43%. 90-95% of the product is metabolized in the liver, and is mainly combined with glucuronic acid, sulfuric acid and cysteine. Intermediate metabolites have toxic effects on the liver. The half-life β is generally 1 to 4 hours (2 hours on average), and the renal insufficiency remains unchanged, but it may be prolonged in some patients with liver disease, the elderly and newborns may be prolonged, and children may be shortened. The plasma concentration can reach the peak value 0.5~2 hours after oral administration. When the dose is less than 650mg, the plasma concentration is 5~20μg/ml, and the duration of action is 3~4 hours. During breastfeeding, women take 650mg of this product, and the concentration in milk is 10-15μg/ml within 1~2 hours; the half-life β is 1.35~3.5 hours. The product is mainly excreted from the kidney in the form of binding with glucuronic acid, and about 3% of it is excreted in the urine in its original form within 24 hours.
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It is suitable for alleviating mild to moderate pain, such as fever, headache, joint pain, neuralgia, migraine, dysmenorrhea, etc. caused by a cold. Because this product can only relieve symptoms, has no or minimal anti-inflammatory effect, and cannot eliminate redness, swelling, and movement disorders caused by arthritis, it cannot be used to replace aspirin or other non-steroidal anti-inflammatory drugs to treat various types of arthritis. However, the product can be used for cases that are allergic to, intolerant to, or not suitable for aspirin, such as patients with chickenpox, hemophilia and other bleeding diseases (including those with anticoagulation therapy), as well as peptic ulcers, gastritis, etc. When using this product, other therapies must also be used to relieve the cause of pain or fever when necessary.
It is used for fever caused by common cold or influenza. It is also used to relieve mild to moderate pain such as joint pain, migraine, headache, muscle pain, toothache, dysmenorrhea, and neuralgia.
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