Indication symptom:
.It can be used for mild to moderate pain, such as fever, headache, joint pain, neuralgia, and pain, etc.
The goods can only relieve symptoms, anti-inflammatory effects no or very little, can't eliminate the redness, swelling, arthritis activity obstacle, so can't to replace aspirin or other non-steroidal anti-inflammatory drug treatment of all types of arthritis.
But the goods can be used for allergic to aspirin, intolerance, or is not suitable for application cases of aspirin, such as chickenpox, patients with hemophilia and other hemorrhagic diseases (including cases of application of anticoagulant therapy), and peptic ulcer, gastritis, etc.
If necessary, the application should be applied to other treatments to relieve pain or fever.
Usage and dosage:
| Adult |
0.3g-0.6g per time |
4 times per day |
| Children |
10mg-15mg / kg per time |
taken every 4-6 hours |
1. Oral administration of adults.
One time between 0.3 and 0.6 g, 1 time every 4 hours, or 4 times per day;
Should not exceed 2g in a day, the course of treatment for fever generally no more than 3 days, should not be more than 10 days for pain relief.
2. Oral administration of children.
According to the weight of 10 to 15mg/kg, or 1.5 g/m per day according to the body surface area, the subs will be taken every 4 to 6 hours.
Children under the age of 12 shall not exceed 5 times per 24 hours, or less than 5 days.
White and black, parke, tylenol cold, cold, pain, and so on all contain acetaminophen, dose about 120 to 500 mg.
Toxic and side reactions:
But the widespread use of clinical, the emergence of some toxic side reactions , must arouse people's vigilance.
1. Adverse reactions of liver: prolonged or overdose can cause liver cell necrosis.
Paracetamol cause liver cell necrosis is its direct effects on liver cells, may be an overdose of acetaminophen causes the body to generate a toxic metabolite, when accumulated to a certain amount, cause liver GSH depletion, decreased liver detoxification capacity greatly, toxic metabolite destroy liver cells and produce cell degeneration and necrosis.
Due to excessive paracetamol of the heart necrosis of acute hepatic lobules, rapid progression of sudden liver failure and death.
The side reaction of 2, kidney: excessive toxic metabolites generated paracetamol also can damage the kidneys and cause renal cell necrosis, especially share sodium salicylate , are more likely to damage the kidneys.
3, the side reaction of blood system: long-term excessive paracetamol, toxic metabolites can be generated by direct effects on bone marrow hematopoietic system, constitute the damage, can also induce thrombocytopenic purpura or leukemia.
4, the side reaction of the nervous system: if children with an overdose of acetaminophen, also can cause the symptoms of the central nervous system, mainly in the brain damage, neurologic impairment, coma, and so on.
Rarely, if allergic reaction should be stopped immediately.
Notes:
· take an overdose of medicine immediately.
· not to be taken with other drugs containing acetaminophen.
· if there is a severe sore throat, accompanied by fever, headache skin, nausea or vomiting, please consult a doctor.
· avoid alcoholic beverages while taking the medicine, and the drinker should take the product and other painkillers under the guidance of the doctor.
Taking paracetamol in the following situations can cause liver damage
(1) overdose.
(2) take long and high doses.
(3) drink or drink alcoholic beverages.
(4) small doses of liver disease can also damage the liver.
(5) mix it with other acetaminophen headaches, cold medications and other medications.
In a study of 300 patients with severe liver failure, American researchers found that 38 percent of the cases were related to acetaminophen.
In another group of 307 adults suffering from severe liver damage, 35 percent of the cases were linked to acetaminophen.
Most of these cases are accidental, due to inattention.
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