Element
The main ingredient of this product is norfloxacin.
Traits
This product is a film-coated tablet, which is almost white to light yellow after removing the coating.
Indications
This product is suitable for urinary tract infections, gonorrhea, prostatitis, intestinal infections, typhoid fever and other salmonella infections caused by sensitive bacteria.
Specification
0.1g.
Dosage
oral.
1. Acute simple lower urinary tract infections caused by Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis 400mg once, twice a day, and the course of treatment is 3 days.
2. The dosage for simple urinary tract infections caused by other pathogenic bacteria is the same as above, and the course of treatment is 7-10 days.
3. The dose for complicated urinary tract infections is the same as above, and the course of treatment is 10-21 days.
4. Simple gonococcal urethritis: 800-1200 mg per dose.
5. Acute and chronic prostatitis: 400mg once, 2 times a day, the course of treatment is 28 days.
6. Intestinal infection: 300-400mg once, twice a day, the course of treatment is 5-7 days.
7. Salmonella typhi infection: 800-1200mg a day, divided into 2-3 times, the course of treatment is 14-21 days.
Adverse reactions
1. Gastrointestinal reactions are more common, which can be manifested as abdominal discomfort or pain, diarrhea, nausea or vomiting.
2. Central nervous system reactions may include dizziness, headache, drowsiness or insomnia.
3. Allergic reactions: rash, skin itching, exudative erythema multiforme and angioneurotic edema occasionally, and a few patients have photosensitivity reactions.
4. Occasionally.
(1) Seizures, mental disorders, irritability, disturbance of consciousness, hallucinations, tremors.
(2) Interstitial nephritis such as hematuria, fever, and rash.
(3) Phlebitis.
(4) Crystaluria, which is more common in high-dose applications.
(5) Joint pain.
5. A small number of patients may have increased serum aminotransferase, increased blood urea nitrogen and decreased peripheral blood white blood cells, most of which are mild and transient.
Taboo
Patients who are allergic to this product and fluoroquinolones are contraindicated.
Precautions
1. This product should be taken on an empty stomach with 250ml of water.
2. Patients with glucose-6-phosphate dehydrogenase deficiency who take this product may have hemolysis in rare cases.
3. Crystaluria may occur when the product is used in large doses or when the urine pH is above 7. In order to avoid the occurrence of crystaluria, it is advisable to drink more water and maintain a 24-hour urine output above 1200ml.
4. For patients with impaired renal function, the dosage should be adjusted according to renal function.
5. Moderate and severe photosensitivity reactions can occur when using fluoroquinolone drugs. Excessive exposure to sunlight should be avoided when using this product. If photosensitivity reactions occur, the drug should be discontinued.
6. Since Escherichia coli is more resistant to norfloxacin, urine samples should be collected for culture before administration, and the medication should be adjusted according to the results of bacterial susceptibility.
7. Quinolones, including this product, can aggravate the symptoms of myasthenia gravis, and life-threatening respiratory muscle weakness. Patients with myasthenia gravis should be particularly cautious when using quinolones including this product.
8. When the liver function declines, if it is severe (cirrhotic ascites), it can reduce drug clearance, increase the blood concentration, and the liver and kidney function decline is especially obvious. It is necessary to weigh the pros and cons before application and adjust the dosage.
9. Patients with pre-existing central nervous system diseases, such as those with a history of epilepsy and epilepsy, should avoid the application. When there are indications, it is necessary to carefully weigh the advantages and disadvantages before applying.
10. Medication for pregnant women and lactating women: I have used monkeys for reproduction studies. The dosage is 10 times the human dosage. It is found that this product can cause miscarriage. The peak plasma concentration of this dosage in monkeys is about 2 times that of humans. Teratogenic effects have not been confirmed in animals. However, suitable and well-controlled studies have not been carried out in pregnant women. Therefore, this product is not suitable for pregnant women. There is no information on whether this product is secreted by milk. When lactating women use 200mg of this product When the drug cannot be detected in breast milk, however, due to the small study dose, and other varieties of this drug are secreted by breast milk, and the potential for serious adverse reactions to newborns and infants, lactating women should avoid using this product or Stop breastfeeding during application.
11. Pediatric medication: it is forbidden for patients under 18 years of age.
12. Medication for elderly patients: Elderly patients often have renal dysfunction. Because part of this product is excreted through the kidneys, it needs to be used in a reduced amount.
13. Overdose: It is not clear yet.
Pharmacological action
1. This product is a fluoroquinolone antibacterial drug with a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic gram-negative bacilli, and has a good antibacterial effect in vitro against the following bacteria: most bacteria in the Enterobacteriaceae family, including Citrobacter, Enterobacter cloacae, Enterobacter aerogenes and other Enterobacter species, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia Bacteria etc. Norfloxacin also has antibacterial activity against multi-drug resistant bacteria in vitro. Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella catarrhalis which are resistant to penicillin also have good antibacterial effects.
2. Norfloxacin is a bactericide, which inhibits DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase, leading to bacterial death.
storage
Shading, sealed and stored.
Valid period 36months
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