Metoclopramide, also known as chlorpramide, English name metoclopramide, molecular formula is C14H22ClN3O2, molecular weight is 299.7964, CAS registration number is 364-62-5, white to light yellow crystalline powder, has a powerful central antiemetic Function, used for nausea, vomiting, belching, loss of appetite, indigestion, etc.
Basic Information
Chinese name: Metoclopramide
English name: metoclopramide
Chinese aliases: metoclopramide; metuling; mettoning; chlorpramide
English alias: 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide
CAS Number: 364-62-5[1]
Molecular formula: C14H22ClN3O2
Molecular weight: 299.7964
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1. Physical data
Properties: white to light yellow crystalline powder, odorless, bitter taste
Density (g/mL, 25/4ºC): not available
Relative vapor density (g/mL, air=1): not available
Melting point (ºC): 147-151
Boiling point (ºC, normal pressure): not available
Boiling point (ºC, 5.2kPa): not available
Refractive index: not available
Flash point (ºC): not available
Specific rotation (º): Not available
Auto-ignition point or ignition temperature (ºC): Not available
Vapor pressure (kPa, 25ºC): Not available
Saturated vapor pressure (kPa, 60ºC): not available
Heat of combustion (KJ/mol): Not available
Critical temperature (ºC): not available
Critical pressure (KPa): not available
Log value of oil-water (octanol/water) partition coefficient: not available
Upper explosion limit (%,V/V): not available
Lower explosion limit (%,V/V): not available
Solubility: soluble in water and ethanol, insoluble in benzene and ether, slightly soluble in acetone
Synthesizing method of this section
It is obtained by esterification, acylation and methylation of p-aminosalicylic acid to obtain methyl p-acetamido·o-methoxybenzoate, and then chlorination, amination and hydrolysis.
The main purpose of this paragraph
It has a powerful central antiemetic effect and is used for nausea, vomiting, belching, loss of appetite, and indigestion.
Collapse edit this paragraph system number
CAS Number: 364-62-5
EINECS number: 206-662-9
Collapse edit this paragraph of toxicological data
2. Toxicological data:
Acute toxicity: Not available.
Fold to edit the molecular structure data of this paragraph
1. Molar refractive index: 83.03
2. Molar volume (m3/mol): 258.7
3. Isotonic specific volume (90.2K): 665.3
4. Surface tension (dyne/cm): 43.6
5. Polarizability (10-24cm3): 32.91
Collapse edit this paragraph of ecological data
3. Ecological data:
1. Other harmful effects: This substance may be harmful to the environment, so special attention should be paid to water bodies.
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